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Chris Rock
Osmosis Jones (voice)
Laurence Fishburne
Thrax (voice)
David Hyde Pierce
Drix (voice)
Brandy Norwood
Leah (voice)
Bill Murray
Frank Detorre
Molly Shannon
Mrs. Boyd
William Shatner
Mayor Phlegmming (voice)
Ron Howard
Tom Colonic (voice)
Sherry Lynn
(voice)
Mickie McGowan
Additional Character Voice (voice)
$ 75,000,000
$ 13,596,911
Released
Conundrum Entertainment
Warner Bros. Pictures
Bobby Farrelly
Producer
Lois Freeman-Fox
Editor
Director
Randy Edelman
Original Music Composer
