Frank Infante (born November 15, 1951) is an American guitarist and bassist best known as a former member of the new wave band Blondie. Infante began his music career playing guitar in hard rock and electric blues groups such as The Elegant End and World War III.

He joined Sniper in 1975 and then Blondie in 1977 as a session player, replacing bassist Gary Valentine. Blondie released their second album Plastic Letters in 1978. Infante played bass and guitar on the album but was not pictured on its cover.