Matteo van der Grijn completed his education in 2007 at the Theatre School Arnhem. After his education, Matteo started his career in the performance Hamlet, by the Theater Company, directed by Theu Boermans.

In addition, he appeared in various productions of the National Theater: Levende Doden, De Prooi and A midsummer night's dream. In the 2010/2011 season Matteo was the first actor to play the title role in the musical Soldier of Orange directed by Theu Boermans and in 2014/2015 he played at the National Theater in Blauwdruk Voor Een Nog Beter Leven directed by Johan Doesburg. He was also the lead in Fatal Attraction and Indecent Proposal, among others.