Prometheus Aleifer was born in 1982 in Athens, Greece. His birth name is Spyros Promitheas Aliferopoulos.

He studied theater at the University of Athens and the Art Theater Drama School. Right after school he joined the National Theater in Athens and worked on numerous productions of classical and contemporary plays under the direction of famous European directors . He did his first feature film "Burning heads" (original title "Milk") in 2011.