Nuccia Focile (born 25 November 1961) is an Italian operatic soprano. Nuccia Focile was born in Militello in Val di Catania, Sicily, studied in Turin under Elio Battaglia, and made her opera debut in 1983 as Serpina in La Serva Padrona by Pergolesi in Spoleto.

In 1984 she sang her first Mimi in La Boheme by Puccini at the Teatro Regio in Turin and made her debut as Oscar in Verdi's Un ballo in maschera at La Scala in 1986. Also in that year, she won the International Pavarotti Competition in Philadelphia, following which she made many concert appearances with the famous tenor. In 1995 she made her Metropolitan Opera debut as Mimì in Puccini's La bohème.