Elena Topalidou was born in Athens. She studied dance at the State School of Orchestral Art and piano at the National Conservatory of Athens.

As a dancer she was a key member of the OKTANA dance theater from 1993 to 2005 and participated in all its productions. She also collaborated with Dimitris Papaioannou and the Ground Team, the National Theatre, the State Theater of Northern Greece, the Rootless root group, etc. As an actor, she collaborated with the National Theatre, KTHBE, the Athens Festival, the House of Letters and Arts, etc.