Riele Downs booked her first feature film role in the late John Singleton's Four Brothers (2005), opposite Mark Wahlberg and Terrence Howard. Riele went on to book multiple film roles including The Best Man Holiday (2013) and The Gabby Douglas Story (2014).

Riele stars as Charlotte, the no-nonsense voice of reason on CBS's superhero comedy series Henry Danger (2014-20) which had a successful 121 episode run, which won multiple awards, including her 2020 Kid's Choice Awards nomination for "Favorite Female TV Star". Her animation credits include the award-winning Peep and the Big Wide World, The Adventures of Kid Danger and Captain Man, and S.A.