Luttazzi was born in Santarcangelo di Romagna, province of Rimini. He began his comic career performing satirical monologues in theatre shows and writing comedy books.

In 1988, his monologue won an award in a comedy contest held at Rome's Teatro Sistina. From 1989, he began working in TV variety shows: Fate il vostro gioco (1989, Rai 2), Banane (1989, Telemontecarlo), Magazine 3 (1993, 1994, Rai 3), Mai Dire Gol (1996, 1997, Italia 1). In 1998, he hosts his own late night show, Barracuda (Italia 1).