Saleem Mairaj was born in Karachi, Pakistan. He began his career as a theatre actor and acted in various plays.

He gained popularity through his debut television serial titled "Colony 52" which was aired on Pakistan Television Corporation (now PTV Home) in 1990s. He has since appeared in various television serials. His work in television includes Ishq Ki Inteha (2009), Kash Main Teri Beti Na Hoti (2011), Ullu Baraye Farokht Nahi (2013), Kise Apna Kahein (2014) and Kitni Girhain Baaki Hain (2014).