Jacqueline Lustig was born in Buenos Aires, Argentina. Her debut was in the featured film Alambrado directed by Marco Bechis in the leading role of Eva Logan.

Jacqueline Lustig has lived in Paris and Rome for 17 years working with directors Marco Bellocchio in My Mothers' Smile and La Balia; Thomas Robsahm in The Norvegian featured film S.O.S.