He began his professional studies at the Escuela de Arte Teatral del Instituto Nacional de Bellas Artes (INBA), in 1946, under the teachings of Clementina Otero, Enrique Ruelas, Earl Senett and Seki Sano. He excelled as an actor in numerous plays: Waiting for Godot, by Samuel Beckett; Poor People, by Dostoyevsky; The Diary of a Madman, by Gogol; with which he achieved a memorable dramatization and more than two thousand performances for nearly twenty-five years.

He received awards and distinctions, among them, that of actor emeritus of the Moscow Academy of Theater and Performing Arts for his performance in The Diary of a Madman. Carlos Ancira Negrete, actor and playwright, was one of the initiators of the "Theater of the Absurd" in the 1960s. His interest focuses on the values of a dehumanized society and the loneliness of the individual, thus reflecting the moral and psychological conflicts of a central character to whom the author gave all the dramatic force through the monologue, one of his most successful resources, which in turn led to a theatrical representation in which the essence of the work itself and the performer could be seen with greater effect, above the theatrical or scenographic space.